Search results for "Lithiation reaction"

showing 2 items of 2 documents

Evaluation and synthesis of 7-arylhydroxymethyltriazolopyridines as potential cardiovascular agents

2002

7-Arylhydroxymethyltriazolopyridines 3a-c and 4a-d were synthesized by regioselective lithiation of [1,2,3]triazolo[1,5-a]pyridines 1 and 2 and subsequent trapping of the 7-lithioderivatives formed using aryl aldehydes as electrophiles. The structural relationship between compounds 3a-c and 4a-d and arylethanolamines suggested their consideration as potential cardiovascular agents. A preliminary evaluation as vascular smooth muscle relaxants was carried out. These compounds did not act as α1-adrenoceptor antagonists and were unable to block calcium entry through voltage-dependent calcium channels. Abarca Gonzalez, Belen, Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv…

ChemistryTriazolopyridines ; Lithiation reaction ; α1-adrenoceptor antagonism ; Calcium channels blockadeUNESCO::QUÍMICACalcium channels blockade:QUÍMICA::Química orgánica [UNESCO]Organic Chemistry:QUÍMICA [UNESCO]lcsh:QD241-441lcsh:Organic chemistryCardiovascular agentTriazolopyridinesα1-adrenoceptor antagonismUNESCO::QUÍMICA::Química orgánicaLithiation reactionHumanities
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Triazolopyridines 23.1 Synthesis of 5,5'-bi[1,2,3]triazolo[5,1-a]isoquinoline

2004

5,5'-Bi[1,2,3]triazolo[5,1-a]isoquinoline 6 has been synthesised from [1,2,3]triazolo[5,1-a] isoquinoline 5 by four procedures, dimerisation by LDA, Stille and Suzuki self-coupling reactions, and Suzuki cross-coupling reaction. The last is the best. Compound 6 gives 1,1'- bi(acetoxymethyl)-3,3'-biisoquinoline 10 by triazolo ring opening by acetic acid. Abarca Gonzalez, Belen, Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv.es ; Gay Roig, Bernat, bergay@alumni.uv.es

Self-coupling and cross-coupling reactionsBitriazoloisoquinolines ; Triazoloisoquinolines ; Lithiation reaction ; Self-coupling and cross-coupling reactionsUNESCO::QUÍMICA:QUÍMICA::Química orgánica [UNESCO]Lithiation reactionUNESCO::QUÍMICA::Química orgánicaBitriazoloisoquinolinesTriazoloisoquinolines:QUÍMICA [UNESCO]
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